Letter from Francis Crick to Aaron Klug


Title:
Letter from Francis Crick to Aaron Klug
Description:
Crick here commented further on the draft of a paper by Klug on the spatial arrangement of DNA and histones (proteins associated with DNA) in nucleosomes. Particularly, Crick debated the dimensions of the DNA helix in nucleosomes and how the DNA helix was itself coiled in a nucleosome (forming a coiled coil, or superhelix). Nucleosomes have since been determined to consist of eight histone molecules wrapped by a DNA segment of about 150 base pairs in length. Under the electron microscope nucleosomes, which are linked to each other by DNA sequences about fifty base pairs in length, appear as bead-like bodies on a string.
Extent:
2 pages
Date Created:
20 June 1977
Creator:
Crick, Francis, 1916-2004
Recipient:
Klug, Aaron (Aaron Klug)
Source:
Original Repository. Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers. 11646. URL. http://archives.wellcome.ac.uk/
Original Repository:
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Right Type:
Permission Granted - No Conditions
Right Statement:
Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine. and http://library.wellcome.ac.uk/
Subject:
DNA and Nucleosomes
Profiles in Science ID:
SCBBQH
NLM ID:
101584582X232
Genre:
Letters (correspondence)
Language:
English
Format:
Text
Location:
Box: 23. Folder: PP/CRI/D/2/18