Letter from Francis Crick to Aaron Klug


Title:
Letter from Francis Crick to Aaron Klug
Creator:
Crick, Francis, 1916-2004
Recipient:
Klug, Aaron
Date:
4 October 1977
Description:
Crick here evaluated research results by two of his coauthors, Leth Bak and Jesper Zeuthen, used in an article the three wrote on the structure and folding of DNA and its associated proteins in human chromosomes during cell division (mitosis). In their article they postulated that chromatids, the one-half of a chromosome that splits off from the other half during cell division, were organized in a hierarchy of helices: the chromatid is a folded and coiled super-solenoid (a long, regular, hollow cylindrical structure), also called the unit fiber, which in turn is formed by a coiled solenoid of smaller diameter, which in turn is formed by coiling the string of nucleosomes, bead-like complexes of DNA and protein.. See Leth Bak, Jesper Zeuthen, and Crick, "Higher-Order Structure of Human Mitotic Chromosomes," Proceedings of the National Academy of Sciences, vol. 74 (April 1977), pp. 1595-99.
Original Repository:
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Location:
Box: 23. Folder: PP/CRI/D/2/19
Rights:
Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine. and http://library.wellcome.ac.uk/
Genre:
Letters (correspondence)
Subject:
DNA and Chromosomes
Format:
Text
Extent:
2 pages
Relation:
Letter from Aaron Klug to Francis Crick, 1977
Higher-Order Structure of Human Mitotic Chromosomes, 1977
Language:
English
Legacy Source Citation:
Original Repository. Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers. 11646. URL. http://archives.wellcome.ac.uk/
Legacy ID:
SCBBQW
NLM ID:
101584582X244
Profiles Collection:
The Francis Crick Papers
Story Section:
From Molecular Biology to Neurobiology, 1976-2004