Letter from Francis Crick to Robert W. Holley


Title:
Letter from Francis Crick to Robert W. Holley
Creator:
Crick, Francis, 1916-2004
Recipient:
Holley, Robert W.
Date:
30 November 1966
Description:
Crick here reported on ongoing genetic work in his and Sydney Brenner's laboratory, work designed to complete the elucidation of the genetic code by identifying the codons in the transfer RNA for each amino acid (here, methionine) that bind to the complementary codon on the messenger RNA template, and by identifying those so-called nonsense triplets that do not code for any amino acid. Hydroxylamine is a chemical that is structurally analogous to the DNA bases, and when supplied in the food of the microorganisms used in genetic experiments (the research discussed by Crick focused on the much-studied rII gene of the bacteriophage T4), could be substituted for the regular base during gene replication, producing a mutation in the gene.. Holley, who was to win a share of the Nobel Prize in Physiology or Medicine in 1968, obtained the first sequence of a nucleic acid, the seventy-seven nucleotide-long strand of alanine tRNA of yeast.
Original Repository:
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Location:
Box: 37. Folder: PP/CRI/E/1/14/6
Rights:
Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine. and http://library.wellcome.ac.uk/
Genre:
Letters (correspondence)
Subject:
Genetic Code
Format:
Text
Extent:
2 pages
Language:
English
Legacy Source Citation:
Original Repository. Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers. 11646. URL. http://archives.wellcome.ac.uk/
Legacy ID:
SCBBDG
NLM ID:
101584582X35
Profiles Collection:
The Francis Crick Papers
Story Section:
Deciphering the Genetic Code, 1958-1966