Structure of Small Viruses


Title:
Structure of Small Viruses
Description:
Renewing their collaboration during Watson's return to the Cavendish laboratory in the fall of 1955, Watson and Crick in this article laid out a theory for explaining why all plant viruses whose structure had been studied up to that time were very similar in shape, either rod-shaped (cylindrical) or spherical. In developing their theory they once again benefited from their complementary expertise, namely Crick's extensive knowledge of X-ray crystallography and Watson's previous studies with tobacco mosaic virus and ribonucleic acid. They proposed that plant viruses consistently took one of two shapes because the two chemical components of which they were made up, ribonucleic acid surrounded by a large number of identical protein subunits, were assembled according to a general plan that was determined by "symmetry elements," structural requirements imposed by the shape of each protein subunit and by the angles of the bonds they formed with the ribonucleic acid core.
Extent:
3 pages
Date Issued:
10 March 1956
Creator:
Crick, Francis, 1916-2004 and Watson, James D. (James D. Watson)
Source:
Periodical. Crick, Francis, and James D. Watson. "Structure of Small Viruses." Nature 177, 4506 (10 March 1956): 473-475. Article. 3 Images.. Nature
Periodical:
Nature
Publisher:
Nature Publishing Group
Right Type:
Permission Granted - No Conditions
Right Statement:
Reproduced with permission of the Nature Publishing Group. and http://www.nature.com/nature/
Profiles in Science ID:
SCBBZN
NLM ID:
101584582X395
Genre:
Articles
Language:
English
Format:
Text