General Model for the Chromosomes of Higher Organisms


Title:
General Model for the Chromosomes of Higher Organisms
Description:
Crick here proposed a general model for the structure of chromosomes in higher eukaryotic cells. His model was designed to account for discoveries made during the 1960s that most of the DNA in higher organisms did not code for proteins but carried out genetic control functions, and that chromosomal DNA was most often associated with proteins, mainly histones, rather than in its pure double-helical form. Crick's model posited that chromosomal DNA consisted of "bands" of highly folded, unpaired single-stranded segments of double-stranded DNA, which carried out control functions. In between these stretches of "globular" DNA were much shorter stretches of "fibrous" DNA, similarly unpaired and single-stranded but extended and not folded, which coded for proteins.
Extent:
3 pages
Date Issued:
5 November 1971
Creator:
Crick, Francis, 1916-2004
Source:
Periodical. Crick, Francis. "General Model for the Chromosomes of Higher Organisms." Nature 234, (5 November 1971): 25-27. Article. 3 Images.. Nature
Periodical:
Nature
Publisher:
Nature Publishing Group
Right Type:
Permission Granted - No Conditions
Right Statement:
Reproduced with permission of the Nature Publishing Group. and http://www.nature.com/nature/index.html
Profiles in Science ID:
SCBCCM
NLM ID:
101584582X434
Genre:
Articles
Language:
English
Format:
Text