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In this conceptual outline, addressed to James Watson and Leslie Orgel, Crick considered how a genetic code that is non-overlapping--i.e., in which discrete units of nucleotides, whether triplets or quadruplets, do not share nucleotides with each other--might still have enough built-in restrictions to code for only twenty amino acids during protein synthesis.
Original Repository:
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Location:
Box: 74. Folder: PP/CRI/H/2/2
Rights:
Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine. and http://library.wellcome.ac.uk/
Original Repository. Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers. 11646. URL. http://archives.wellcome.ac.uk/