What Are the Properties of Genetic RNA?: A Note for the RNA Tie Club


Title:
What Are the Properties of Genetic RNA?: A Note for the RNA Tie Club
Creator:
Crick, Francis, 1916-2004
Brenner, Sydney
Date:
May 1960
Description:
In this note, which remained in manuscript form and was never circulated, Crick and Brenner came to terms with the results of the famous "PaJaMo" experiment of Arthur Pardee, Francois Jacob, and Jacques Monod, which implied that ribosomal RNA could not be, as had long been assumed, the messenger that carried genetic information from DNA in the cell nucleus to the ribosome, the site of protein synthesis in the cytoplasm of the cell. Instead, Crick and Brenner here announced a new "messenger hypothesis," first developed at a famous meeting in Cambridge with Francois Jacob and others on Good Friday, 1960. According to the messenger hypothesis, genetic instructions were relayed by a distinct form of messenger RNA, which had in fact been unwittingly observed by researchers before, and which was soon to be purposefully isolated in the laboratory. This profound insight cleared the way for the elucidation of the genetic code.
Original Repository:
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Location:
Box: 81. Folder: PP/CRI/H/2/41
Rights:
Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine. and http://library.wellcome.ac.uk/
Genre:
Articles
Subject:
Genetic Code and RNA
Format:
Text
Extent:
20 pages
Language:
English
Legacy Source Citation:
Original Repository. Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers. 11646. URL. http://archives.wellcome.ac.uk/
Legacy ID:
SCBBFZ
NLM ID:
101584582X70
Profiles Collection:
The Francis Crick Papers
Story Section:
Deciphering the Genetic Code, 1958-1966