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Lerman obtained physical chemical evidence that chemicals of the acridine type, specifically proflavin, produced mutations in genes by which individual bases where added to, or deleted from, the base sequence, thereby changing the sequence and, with it, the order of the amino acids in the protein for which the gene coded. By contrast, other mutations consist of substitutions of bases.
Original Repository:
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Location:
Box: 10. Folder: PP/CRI/D/1/1/12
Rights:
Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine. and http://library.wellcome.ac.uk/
Original Repository. Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers. 11646. URL. http://archives.wellcome.ac.uk/