Title:

Letter from Francis Crick to Arthur Kornberg

Creator:

Crick, Francis, 1916-2004

Recipient:

Kornberg, Arthur, 1918-2007

Date:

9 February 1962

Description:

Crick here discussed continued efforts to decipher the genetic code, in particular the use of base-equivalents such as bromouracil (chemically very similar to the base uracil in RNA) to induce mutations, specifically the substitution of one base by another. The second laboratory method mentioned was the synthesis of strands of RNA of known, simple, repetitive sequence (Crick here referred to poly AU) as a means of finding out which triplets of bases code for which amino acids (a sequence of AUAUAUAUA etc. codes for the polypeptide isoleucine-tyrosine-isoleucine-tyrosine etc).

Original Repository:

The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers

Location:

Box: 9. Folder: PP/CRI/D/1/1/11

Rights:

Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine. and http://library.wellcome.ac.uk/

Genre:

Letters (correspondence)

Subject:

Genetic Code and RNA

Format:

Text

Extent:

1 pages

Language:

English

Legacy Source Citation:

Original Repository. Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers. 11646. URL. http://archives.wellcome.ac.uk/

Legacy ID:

SCBBGY

NLM ID:

101584582X88

Profiles Collection:

The Francis Crick Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584582X88

Story Section:

"Creating Life in the Test Tube," 1959-1970