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Sinsheimer, Robert and California Institute of Technology
Date:
29 July 1965
Description:
Working to synthesize a viable DNA, Kornberg turned to the small bacterial viruses M13 and Phi X174. Biophysicist Robert Sinsheimer at the California Institute of Technology had found that the single-stranded, circular Phi X174 virus DNA was converted to a double helix after entering its E. coli host, and by itself was infective. In a previous letter, Kornberg had asked for a sample of Sinsheimer's virus to start investigating its possible use as a replication template. This letter reported on his initial results with the virus. It was from this virus that Kornberg was able to create an infective synthetic viral DNA in 1967.
Original Repository:
Stanford University Libraries. Department of Special Collections and University Archives. Arthur Kornberg Papers