Official websites use .gov A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
In 1957, Freis was the first to announce the treatment of hypertension with the diuretic chlorothiazide. Especially when taken in conjunction with other drugs, chlorothiazide proved extremely effective at lowering blood pressure. In this follow-up to a paper on chlorothiazide Freis presented with Ilse Wilson in 1959, he further discussed the drug's effectiveness as well as the role salt plays in hypertension.
Periodical. Freis, Edward D. "Mechanism of the Antihypertensive Effects of Diuretics: Possible Role of Salt in Hypertension." Clinical Pharmacology and Therapeutics 1, 3 ([May-June 1960]): 337-344. Article. 8 Images.. Clinical Pharmacology and Therapeutics