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In this article, Freis's team compared oxprenolol and propranolol, both beta-adrenergic blocking agents, in mild and moderate hypertension patients who had not responded well to the diuretic hydrochlorothiazide. They found that after six months a significant reduction in blood pressure occurred in half of the patients that took propranolol along with the diuretic, whereas only twenty-seven percent of the patients that took oxprenolol with a diuretic achieved similar results.