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Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension: I. Results of Short-Term Titration with Emphasis on Racial Differences in Response
- Title:
- Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension: I. Results of Short-Term Titration with Emphasis on Racial Differences in Response
- Creator:
- Veterans Administration Cooperative Study Group on Antihypertensive Agents
- Date:
- [22/29 October 1982]
- Description:
- Propranolol, a beta-adrenergic antagonist (beta-blocker), was developed in the 1960s. By slowing the heart rate and pumping volume, it also lowers blood pressure, and so was used to control hypertension. By the late 1970s a few experts had suggested that propranolol, effective and well-tolerated by many patients, might replace thiazide diuretics as the first step in hypertension treatment. In this article Freis and his colleagues report on a clinical trial that compared the two drugs. They found that they worked equally well in white patients, but that the diuretic hydrochlorothiazide worked better in African-American patients. They recommended that treatment continue to be based on assessment of the individual patient, and that it include a consideration of medication costs; propranolol could cost more than 20 times as much for equivalent doses as hydrochlorothiazide.. NOTE: This was the best scan that could be obtained (photocopy is of poor quality).
- Periodical:
- Journal of the American Medical Association
- Publisher:
- American Medical Association
- Location:
- Box: 7. Folder: 12
- Rights:
- Public Domain
- Genre:
- Articles
- Subject:
- Hypertension, Antihypertensive Agents, Hydrochlorothiazide, and Propranolol
- Format:
- Text
- Extent:
- 8 pages
- Relation:
- Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension: II. Results of Long-Term Therapy, 1982
- Language:
- English
- Legacy Source Citation:
- Periodical. Veterans Administration Cooperative Study Group on Antihypertensive Agents. "Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension: I. Results of Short-Term Titration with Emphasis on Racial Differences in Response." Journal of the American Medical Association 248, 16 ([22/29 October 1982]): 1996-2003. Article. 8 Images.. Journal of the American Medical Association
- Legacy ID:
- XFBBLX
- NLM ID:
- 101584929X183
- Profiles Collection:
- The Edward D. Freis Papers
- Shareable Link:
- https://profiles.nlm.nih.gov/101584929X183
- Story Section:
- After 1980: Changing Trends in Hypertension Therapy