Assay in Man of the Chemical Fractions of Veratrum Viride, and Identification of the Pure Alkaloids Germitrine and Germidine as Potent Hypotensive Principles Derived from the Drug

Title:
Assay in Man of the Chemical Fractions of Veratrum Viride, and Identification of the Pure Alkaloids Germitrine and Germidine as Potent Hypotensive Principles Derived from the Drug
Creator:
Freis, Edward D.
Stanton, Joseph R.
Moister, F. Corbin
Date:
February 1950
Description:
Veratrum viride was a common herbal remedy for high blood pressure. By the late 1940s, it was widely recognized as a useful antihypertensive agent, however it unfortunately produced side effects such as violent retching, nausea, and vomiting. Freis and several of his colleagues at various Boston hospitals attempted to separate the active antihypertensive components of the drug from its emetic effects. In this article, they reported that they had successfully extracted two previously undiscovered active alkaloids (germitrine and germidine) that lowered blood pressure without the deleterious side effects.
Periodical:
Journal of Pharmacology and Experimental Therapeutics
Publisher:
Williams & Wilkins
Location:
Box: 7. Folder: 8
Rights:
Public Domain
Genre:
Articles
Subject:
Hypertension, Antihypertensive Agents, and Veratrum
Format:
Text
Extent:
8 pages
Language:
English
Legacy Source Citation:
Periodical. Freis, Edward D., Joseph R. Stanton, and F. Corbin Moister. "Assay in Man of the Chemical Fractions of Veratrum Viride, and Identification of the Pure Alkaloids Germitrine and Germidine as Potent Hypotensive Principles Derived from the Drug." Journal of Pharmacology and Experimental Therapeutics 98, 2 (February 1950): 166-173. Article. 8 Images.. Journal of Pharmacology and Experimental Therapeutics
Legacy ID:
XFBBCN
NLM ID:
101584929X32
Profiles Collection:
The Edward D. Freis Papers
Shareable Link:
https://profiles.nlm.nih.gov/101584929X32
Story Section:
Early Career and Work with Antihypertensive Drugs, 1940-1949