Captopril: Evaluation of Low Doses, Twice-Daily Doses and the Addition of Diuretic for the Treatment of Mild to Moderate Hypertension

Title:
Captopril: Evaluation of Low Doses, Twice-Daily Doses and the Addition of Diuretic for the Treatment of Mild to Moderate Hypertension
Creator:
Veterans Administration Cooperative Study Group on Antihypertensive Agents
Date:
1982
Description:
In the early 1980s, a new class of drugs were developed that treated hypertension by preventing the synthesis of certain hormones that caused blood vessels to constrict. These drugs, of which Captopril was one, were designated as angiotensin converting enzyme (ACE) inhibitors. Freis's team reported that Captopril, which up to then had only been administered to the most severe hypertensive patients, effectively reduced blood pressure in lower doses than indicated in previous studies, reducing the likelihood of deleterious side effects. As a result, they recommended that its use be extended to the general population.
Periodical:
Clinical Science
Publisher:
Medical Research Society (Great Britain)
Location:
Box: 7. Folder: 10
Rights:
Public Domain
Genre:
Articles
Subject:
Hypertension, Antihypertensive Agents, Captopril, and Hydrochlorothiazide
Format:
Text
Extent:
3 pages
Language:
English
Legacy Source Citation:
Periodical. Veterans Administration Cooperative Study Group on Antihypertensive Agents. "Captopril: Evaluation of Low Doses, Twice-Daily Doses and the Addition of Diuretic for the Treatment of Mild to Moderate Hypertension." Clinical Science 63, (1982): 443s-445s. Article. 3 Images.. Clinical Science
Legacy ID:
XFBBCR
NLM ID:
101584929X35
Profiles Collection:
The Edward D. Freis Papers
Shareable Link:
https://profiles.nlm.nih.gov/101584929X35
Story Section:
After 1980: Changing Trends in Hypertension Therapy