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In this review, Freis noted the need for more information on, as well as research in, the effectiveness of cardiovascular drugs. He argued that this can be accomplished by instituting well-designed clinical trials.
Periodical. Freis, Edward D. "Cardiovascular Drugs: Experience of the Drug Efficacy Study (DES)." Circulation XLI, (January 1970): 3-7. Article. 5 Images.. Circulation