A Double Blind Control Study of Antihypertensive Agents: I. Comparative Effectiveness of Reserpine, Reserpine and Hydralazine, and Three Ganglionic Blocking Agents, Chlorisondamine, Mecamyamine, and Pentolinium Tartrate

Title:
A Double Blind Control Study of Antihypertensive Agents: I. Comparative Effectiveness of Reserpine, Reserpine and Hydralazine, and Three Ganglionic Blocking Agents, Chlorisondamine, Mecamyamine, and Pentolinium Tartrate
Creator:
Veterans Administration Cooperative Study Group on Antihypertensive Agents
Date:
July 1960
Description:
In 1956, Freis and a group of physicians in several Veterans Administration hospitals organized a cooperative study group to evaluate antihypertensive agents under well-controlled conditions. In this first of three articles, they reported that various therapeutic regimens were compared in a double-blind control study on 326 hypertensive patients, 232 of whom completed a full year of treatment. The group found that a combination of reserpine (a ganglionic-blocking agent) and hydralazine (a vasodilator) was far more effective than placebos or reserpine alone.
Periodical:
Archives of Internal Medicine
Publisher:
American Medical Association
Location:
Box: 7. Folder: 14
Rights:
Public Domain
Genre:
Articles
Subject:
Hypertension, Antihypertensive Agents, Reserpine, Hydralazine, and Ganglionic Blockers
Format:
Text
Extent:
16 pages
Relation:
Double Blind Control Study of Antihypertensive Agents: II. Further Report on the Comparative Effectiveness of Reserpine, Reserpine and Hydralazine, and Three Ganglion Blocking Agents, Chlorisondamine, Mecamylamine, and Pentolinium Tartrate, 1962
Double Blind Control Study of Antihypertensive Agents: III. Chlorothiazide Alone and in Combination with Other Agents; Preliminary Results, 1962
Language:
English
Legacy Source Citation:
Periodical. Veterans Administration Cooperative Study Group on Antihypertensive Agents. "A Double Blind Control Study of Antihypertensive Agents: I. Comparative Effectiveness of Reserpine, Reserpine and Hydralazine, and Three Ganglionic Blocking Agents, Chlorisondamine, Mecamyamine, and Pentolinium Tartrate." Archives of Internal Medicine 106, (July 1960): 81-96. Article. 16 Images.. Archives of Internal Medicine
Legacy ID:
XFBBDY
NLM ID:
101584929X61
Profiles Collection:
The Edward D. Freis Papers
Shareable Link:
https://profiles.nlm.nih.gov/101584929X61
Story Section:
The Veterans Administration Hospital and Georgetown University School of Medicine, 1949-1964