Title:

Effect of Pentaquine in Patients with Hypertension

Creator:

Wilkins, Robert W.
Freis, Edward D.

Date:

1947

Description:

Following World War II, Freis returned to Boston to work with Wilkins at Massachusetts Memorial Hospital. Their work on pentaquine was an outgrowth of anti-malarial work conducted by others during the war, in which it was observed that some volunteers developed orthostatic hypotension. In this article, they report that the drug did lower blood pressure, yet it would not be an effective antihypertensive agent because it also produced severe toxic effects.

Periodical:

Proceedings of the Society for Experimental Biology and Medicine

Publisher:

Society for Experimental Biology and Medicine (New York, N.Y.)

Location:

Box: 7. Folder: 15

Rights:

Reproduced with permission of the Society for Experimental Biology and Medicine.

Genre:

Articles

Subject:

Hypertension, Antihypertensive Agents, and Aminoquinolines

Format:

Text

Extent:

4 pages

Language:

English

Legacy Source Citation:

Periodical. Freis, Edward D., and Robert W. Wilkins. "Effect of Pentaquine in Patients with Hypertension." Proceedings of the Society for Experimental Biology and Medicine 64, (1947): 455-458. Article. 4 Images.. Proceedings of the Society for Experimental Biology and Medicine

Legacy ID:

XFBBFH

NLM ID:

101584929X68

Profiles Collection:

The Edward D. Freis Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584929X68

Story Section:

Early Career and Work with Antihypertensive Drugs, 1940-1949