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In this article, Freis reported that hypertension caused structural changes in arteries, which made them more susceptible to atherosclerosis (and therefore coronary artery disease). As a result of these findings, Freis argued for earlier treatment of hypertension.
Periodical. Freis, Edward D. "Hypertension and Atherosclerosis." The American Journal of Medicine 46, 5 (May 1969): 735-740. Article. 6 Images.. The American Journal of Medicine