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In their work with DNA polymerase, Kornberg and his colleagues had found that it could induce a seemingly spontaneous synthesis of an adenine-thymine polymer, without a template. This phenomenon raised a number of questions about the nature of chemical bonds in nucleotides and nucleic acids, and the exact mechanism of the polymerase. In this letter, Henry Sobell asked Kornberg about the feasibility of approaching some of these problems via crystallographic studies and included his research proposal on this topic.
Original Repository:
Stanford University Libraries. Department of Special Collections and University Archives. Arthur Kornberg Papers