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Luria pondered the mechanisms by which multiple mutants arise, and believed that the bacterial mutations discussed here presented analogies with gene mutations in higher organisms. This paper also discussed the identification of single mutation steps in strains with different genotypes and of multiple effects of mutations. Luria spent the 1945-1946 academic year on leave in Cold Spring Harbor, directing a government research project on bacterial resistance to antibiotics. The research produced several papers, including this one.. NOTE: Margin text is skewed in the scanned photocopy.
Periodical:
Cold Spring Harbor Symposia on Quantitative Biology
Periodical. Luria, Salvador E. "Spontaneous Bacterial Mutations to Resistance to Antibacterial Agents." Cold Spring Harbor Symposia on Quantitative Biology 11, (1946): 130-138. Article. 9 Images.. Cold Spring Harbor Symposia on Quantitative Biology