Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension: I. Results of Short-Term Titration with Emphasis on Racial Differences in Response

Title:
Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension: I. Results of Short-Term Titration with Emphasis on Racial Differences in Response
Creator:
Veterans Administration Cooperative Study Group on Antihypertensive Agents
Date:
[22/29 October 1982]
Description:
Propranolol, a beta-adrenergic antagonist (beta-blocker), was developed in the 1960s. By slowing the heart rate and pumping volume, it also lowers blood pressure, and so was used to control hypertension. By the late 1970s a few experts had suggested that propranolol, effective and well-tolerated by many patients, might replace thiazide diuretics as the first step in hypertension treatment. In this article Freis and his colleagues report on a clinical trial that compared the two drugs. They found that they worked equally well in white patients, but that the diuretic hydrochlorothiazide worked better in African-American patients. They recommended that treatment continue to be based on assessment of the individual patient, and that it include a consideration of medication costs; propranolol could cost more than 20 times as much for equivalent doses as hydrochlorothiazide.. NOTE: This was the best scan that could be obtained (photocopy is of poor quality).
Periodical:
Journal of the American Medical Association
Publisher:
American Medical Association
Location:
Box: 7. Folder: 12
Rights:
Public Domain
Genre:
Articles
Subject:
Hypertension, Antihypertensive Agents, Hydrochlorothiazide, and Propranolol
Format:
Text
Extent:
8 pages
Relation:
Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension: II. Results of Long-Term Therapy, 1982
Language:
English
Legacy Source Citation:
Periodical. Veterans Administration Cooperative Study Group on Antihypertensive Agents. "Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension: I. Results of Short-Term Titration with Emphasis on Racial Differences in Response." Journal of the American Medical Association 248, 16 ([22/29 October 1982]): 1996-2003. Article. 8 Images.. Journal of the American Medical Association
Legacy ID:
XFBBLX
NLM ID:
101584929X183
Profiles Collection:
The Edward D. Freis Papers
Shareable Link:
https://profiles.nlm.nih.gov/101584929X183
Story Section:
After 1980: Changing Trends in Hypertension Therapy