Title:

Evaluation of Toxicity in Long-Term Clinical Trials

Creator:

Freis, Edward D.

Date:

1 February 1964

Description:

Along with being a pioneer in hypertension treatment, Freis was a pioneer in the evolution of controlled double-blind clinical trials. In this article, he argued that patients in clinical trials must be protected from hazards by prior trials in animals and acute trials in patients, as well as effective design, careful observation, and prompt reporting of toxicity.

Periodical:

Journal of the American Medical Association

Publisher:

American Medical Association

Location:

Box: 7. Folder: 19

Rights:

Public Domain

Genre:

Articles

Subject:

Hypertension, Antihypertensive Agents, Drug-Related Side Effects and Adverse Reactions, and Clinical Trials as Topic

Format:

Text

Extent:

4 pages

Language:

English

Legacy Source Citation:

Periodical. Freis, Edward D. "Evaluation of Toxicity in Long-Term Clinical Trials." Journal of the American Medical Association 187, 5 (1 February 1964): 352-355. Article. 4 Images.. Journal of the American Medical Association

Legacy ID:

XFBBFY

NLM ID:

101584929X82

Profiles Collection:

The Edward D. Freis Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584929X82

Story Section:

The Veterans Administration Hospital and Georgetown University School of Medicine, 1949-1964