The Soluble Specific Substance of Pneumococcus: IV. On the Nature of the Specific Polysaccharide of Type III Pneumococcus
Throughout the 1920s the scientific community remained skeptical of Avery and Heidelberger's work on the unique antigenic
polysaccharides in type II and type III pneumococcus. Echoing prevailing beliefs among scientists that only proteins could
act as antigens, critics contended that Heidelberger and Avery's polysaccharide solutions had been contaminated by proteins,
and that these, not the polysaccharides, were causing the antigenic reactions. As a result, the two approached Walther Goebel,
an organic chemist, in order to more specifically determine the nature of these polysaccharides and their antigenic properties.
This article details their findings as to the structure and composition of the polysaccharide capsule of type III pneumococcus.
Item is a photocopy.
Number of Image Pages:
12 (1,024,388 Bytes)
1926-11-02 (November 2, 1926)
Goebel, Walther F.
Periodical: Heidelberger, Michael, and Walther F. Goebel. "The Soluble Specific Substance of Pneumococcus: IV. On the Nature of the
Specific Polysaccharide of Type III Pneumococcus." Journal of Biological Chemistry 70, 3 (2 November 1926): 613-624. Article.
[American Society for Biochemistry and Molecular Biology]
This item is in the public domain. It may be used without permission.
Medical Subject Headings (MeSH):
The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927
The "Sugar-Coated Microbe" and the Search for a Cure for Pneumonia, 1919-1929
The Soluble Specific Substance of Pneumococcus (June 1923) (in The Oswald T. Avery Collection)
The Soluble Specific Substance of Pneumococcus: Second Paper (August 1924) (in The Oswald T. Avery Collection)
The Soluble Specific Substance of Pneumococcus: Third Paper (October 1925)
The Soluble Specific Substance of Pneumococcus: V. On the Chemical Nature of the Aldobionic Acid from the Specific Polysaccharide
of Type III Pneumococcus (September 1, 1927)