[Excerpt from Michael Heidelberger's laboratory notebook]
In this entry in his laboratory notebook Heidelberger recorded the results of some early chemical studies of complement, isolated
from the immune serum of rabbits infected with type-II and type-III pneumococcus bacteria. Heidelberger was one of the founders
of the study of complement. In the 1930s, he showed that it consisted of a complex group of protein, today known to number
over twenty, which play an essential enzymatic role in host defense mechanisms against invading organisms.
Raymond Dochez, whose name appears on the first page, in 1923, collaborated with Oswald Avery on isolating the soluble specific
substance of pneumococcus, which they realized to be the capsular material that made each type of the bacteria immunologically-specific
and determined its virulence. Heidelberger later discovered with Avery that the soluble specific substance consisted of polysaccharides--carbohydrates--not
protein, as had widely been assumed.
Item is handwritten.
Number of Image Pages:
7 (38,394,226 Bytes)
October 1916 - June 1917
This item is in the public domain. It may be used without permission.
Medical Subject Headings (MeSH):
Complement System Proteins
The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927