Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine


Profiles in Science
   
Pinterest badge Follow Profiles in Science on Pinterest!

The Christian B. Anfinsen Papers

Title:
Studies on the Reduction and Re-formation of Protein Disulfide Bonds pdf (502,149 Bytes) ocr (17,636 Bytes)
Studies on the Reduction and Re-formation of Protein Disulfide Bonds
Description:
The information contained in the amino acid sequence of a protein is linear, such as it is in DNA, but proteins function by virtue of the arrangement of their linear structure into a well-defined three-dimensional conformation. In this article, Anfinsen and Haber sought to determine how the two-dimensional data of DNA were translated into the three-dimensional information that was characteristic of globular proteins. This simple and elegant experiment was designed to determine what would happen when reduced, unfolded, and enzymatically inactive ribonuclease was allowed simply to refold in the presence of only neutral aqueous buffer and air. They found that most of the activity of the enzyme was regained.
Number of Image Pages:
3 (502,149 Bytes)
Date:
1961-05 (May 1961)
Creator:
Anfinsen, Christian B.
Haber, Edgar
Source:
Periodical: Anfinsen, Christian B., and Edgar Haber. "Studies on the Reduction and Re-formation of Protein Disulfide Bonds." Journal of Biological Chemistry 236, 5 (May 1961): 1361-1363. Article. 3 Images.
Publisher:
American Society for Biochemistry and Molecular Biology
Rights:
Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
URL: http://www.jbc.org/Exit
   Disclaimer; please review our Privacy Policy
Subject:
Medical Subject Headings (MeSH):
Oxidation-Reduction
Ribonucleases
Protein Conformation
Exhibit Category:
Protein Folding and the Thermodynamic Hypothesis, 1950-1962
Box Number: 27
Folder Number: 5
Unique Identifier:
KKBBJV
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Reprints and Research Publications, 1950-1993
SubSeries: Anfinsen Publications, 1954-1993
SubSubSeries: Numbered Reprints
Folder: 81-90
Metadata Last Modified Date:
2006-06-12
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples