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The Christian B. Anfinsen Papers

Title:
A Study of the Factors Influencing the Rate and Extent of Enzymic Reactivation during Reoxidation of Reduced Ribonucelase pdf (861,853 Bytes) ocr (26,703 Bytes)
A Study of the Factors Influencing the Rate and Extent of Enzymic Reactivation during Reoxidation of Reduced Ribonucelase
Description:
In this article, Anfinsen, Epstein, Goldberger, and Young reported their findings of the rate and extent of return of enzymatic activity during oxidation of the sulfhydryl groups of reduced ribonuclease that they studied under a variety of conditions. They found that the rate of reactivation was inversely proportional to the concentration of the reduced portion of ribonuclease. Because of this, these results were inconsistent with the then-prevailing hypothesis that information necessary for the conversion of a newly synthesized polypeptide chain to the native form of the protein resided in the amino acid sequence and did not involve a genetically determined template.
Number of Image Pages:
9 (861,853 Bytes)
Date:
1962
Creator:
Epstein, Charles
Goldberger, Robert
Young, D. Michael
Anfinsen, Christian B.
Source:
Periodical: Epstein, Charles, Robert Goldberger, D. Michael Young, and Christian B. Anfinsen. "A Study of the Factors Influencing the Rate and Extent of Enzymic Reactivation during Reoxidation of Reduced Ribonucelase." Archives of Biochemistry and Biophysics Supplement, (1962): 223-231. Article. 9 Images.
Publisher:
Academic Press
Rights:
This item is in the public domain. It may be used without permission.
Subject:
Medical Subject Headings (MeSH):
Ribonucleases
Disulfides
Enzymes
Peptides
Box Number: 27
Folder Number: 5
Unique Identifier:
KKBBJW
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Reprints and Research Publications, 1950-1993
SubSeries: Anfinsen Publications, 1954-1993
SubSubSeries: Numbered Reprints
Folder: 81-90
Metadata Last Modified Date:
2006-04-10
Linked Data:
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