Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine


Profiles in Science
   
Pinterest badge Follow Profiles in Science on Pinterest!

The Harold Varmus Papers

Title:
Memorandum from Robert J. Huebner, National Institutes of Health to Harold Varmus [regarding Varmus' manuscript on the detection of new and additional virus-specific DNA sequences in chick embryo fibroblasts after infection by RSV] pdf (42,247 Bytes) transcript of pdf
Memorandum from Robert J. Huebner, National Institutes of Health to Harold Varmus [regarding Varmus' manuscript on the detection of new and additional virus-specific DNA sequences in chick embryo fibroblasts after infection by RSV]
Number of Image Pages:
1 (42,247 Bytes)
Date:
1974-05-20 (May 20, 1974)
Creator:
Huebner, Robert J.
National Institutes of Health (U.S.)
Recipient:
Varmus, Harold
Source:
Original Repository: University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers
Rights:
This item is in the public domain. It may be used without permission.
Subject:
Medical Subject Headings (MeSH):
Base Sequence
Avian Sarcoma Viruses
DNA, Viral
Exhibit Category:
Retroviruses and the Genetic Origins of Cancer, 1970-1993
Box Number: 1
Folder Number: 4
Unique Identifier:
MVBBBW
Document Type:
Memorandums
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: UCSF Collections
SubSeries: Collection Number MSS 84-25
SubSubSeries: Correspondence, 1971-1984
Folder: Correspondence, 1974
Transcript:
May 20, 1974
TO: Dr. Harold Varmus
FROM: Dr. Robert Huebner
SUBJECT: MS. -- Detection of new and additional virus-specific DNA sequences in chick embryo fibroblasts after infection by RSV.
This is a very interesting, useful and significant contribution. I think what most needs to be determined is, what is RSV? It's been around 50+ years, is certainly a recombinant, and like AMV according to Rubin, a mixture of several ALV phenotypes (RIF-1, 2, etc.). I would suggest making DNA probes from natural ALV's isolated from RIF-free colonies. Both ecotropic and xenotropic viruses are certainly present and/or activatable. RSV and MSV have not turned up in large numbers of sarcomas in chickens and mice in my 10 years of extensive surveys for natural sarcoma viruses. There has never been one epidemic of sarcoma in any species. Existing RSV and MSV lab strains are laboratory-created artifacts and could not represent faithfully natural virus or viral genomes in natural host cells. There are almost as many variants of RSV and MSV as there are investigators working with them.
Metadata Last Modified Date:
2008-09-23
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples