Role of Sodium and Potassium Ions in Regulation of Glucose Metabolism in Cultured Astroglia
In a short annotated bibliography of the articles he considered his most significant, Sokoloff noted, "Reports studies
with neuronal and astroglial cell cultures demonstrating that glucose utilization in neurons but not in astroglia is stimulated
by increased extracellular K+ concentration (e.g., expected to occur in vivo as a result of increased spike frequency in axonal
terminals) that in turn activates Na+, K+ -ATPase activity. Astroglial glucose utilization is stimulated by glutamate (presumably
released in synapses by functional activation of excitatory pathways); the mechanism of the metabolic stimulation is coupled
uptake of Na+ with the glutamate by the astroglia and consequent activation of Na+, K+ -ATPase activity.)"
Number of Image Pages:
5 (647,425 Bytes)
1995-05 (May 1995)
Driscoll, Bernard F.
Law, Mona J.
National Institute of Mental Health (U.S.)
Periodical: Takahashi, Shinichi, Bernard F. Driscoll, Mona J. Law, Louis Sokoloff, and National Institute of Mental Health (U.S.). "Role
of Sodium and Potassium Ions in Regulation of Glucose Metabolism in Cultured Astroglia." Proceedings of the National Academy
of Sciences of the United States of America 92, 10 (May 1995): 4616-4620. Article. 5 Images.
National Academy of Sciences (U.S.)
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Medical Subject Headings (MeSH):
Positron Emission Tomography Scanning and Beyond, 1979-2004