A Nonhereditary, Host-Induced Variation of Bacterial Viruses
In this article, Luria reported that some bacteria, when infected with phage, would modify the phage in such a way so that
it cannot reproduce in that particular bacteria type. However, the variation gives the phage the ability to infect a different
bacterial species, in this instance Shigella. This is the first instance of the phenomenon of restriction and modification
that would soon after be explained by the discovery of restriction enzymes in bacteria. Luria's work with Human, which
described bacterial restriction-modification systems, eventually led to the discovery of restriction enzymes.
Item is a photocopy.
Number of Image Pages:
13 (1,231,640 Bytes)
1952-10 (October 1952)
Luria, Salvador E.
Human, Mary L.
Periodical: Luria, Salvador E., and Mary L. Human. "A Nonhereditary, Host-Induced Variation of Bacterial Viruses." Journal of
Bacteriology 64, 4 (October 1952): 557-569. Article. 13 Images.
[American Society for Microbiology]
Reproduced with permission of the American Society for Microbiology.
Reproduced with permission of the American Philosophical Society.