Title:

Laboratory project: "Regulation of Adenylate Cyclase by Alpha-Adrenergic Receptors"

Creator:

Sabol, Steven L.
Nirenberg, Marshall W.
National Heart, Lung, and Blood Institute. Laboratory of Biochemical Genetics
Ayukawa, Saburo

Date:

September 1977

Description:

Summary of work on this project as indicated in the report: "The role of the cyclic nucleotides adenosine 3':5' monophosphate (cyclic AMP) and guanosine 3':5' monophosphate (cyclic GMP) in synaptic transmission is under study using cultured cells of neural origin. The topics of interest during the current year have been the following: 1) The alpha-receptor-mediated inhibition of adenylate cyclase activity by norepinephrine in neuroblastoma x glioma hybrid cells; and 2) characterization of a compensatory increase in adeylate cyclase activity in cells treated for 10 hours or longer with norepinephrine and study of the mechanism of this increase, which results in cell tolerance to and dependence on norepinephrine with respect to cyclic AMP synthesis."

Location:

Box: 13. Folder: 35

Rights:

Public Domain

Genre:

Reports
Excerpts

Format:

Text

Extent:

3 pages

Relation:

Annual Report of the Laboratory of Biochemical Genetics, July 1, 1976 - September 1, 1977, 1977

Language:

English

Legacy ID:

JJBBQS

NLM ID:

101584910X264

Profiles Collection:

The Marshall W. Nirenberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584910X264

Story Section:

From Neuroblastoma to Homeobox Genes, 1976-1992