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Heiby developed a theory (similar to homeopathy's law of infinitesimals) known as the reverse effect, that states that "there is a good probability that a vitamin, mineral, or drug that causes or exacerbates a certain disease at one concentration may reverse its role and molify or cure that same disease at another concentration, and vice versa." This is the third letter sent to Nirenberg asking for his comments on the theory, which Heiby promised to include on the jacket for the book.