Title:

Role of Sodium and Potassium Ions in Regulation of Glucose Metabolism in Cultured Astroglia

Creator:

Driscoll, Bernard F.
Law, Mona J.
Sokoloff, Louis
National Institute of Mental Health (U.S.)
Takahashi, Shinichi

Date:

May 1995

Description:

In a short annotated bibliography of the articles he considered his most significant, Sokoloff noted, "Reports studies with neuronal and astroglial cell cultures demonstrating that glucose utilization in neurons but not in astroglia is stimulated by increased extracellular K+ concentration (e.g., expected to occur in vivo as a result of increased spike frequency in axonal terminals) that in turn activates Na+, K+ -ATPase activity. Astroglial glucose utilization is stimulated by glutamate (presumably released in synapses by functional activation of excitatory pathways); the mechanism of the metabolic stimulation is coupled uptake of Na+ with the glutamate by the astroglia and consequent activation of Na+, K+ -ATPase activity.)"

Periodical:

Proceedings of the National Academy of Sciences of the United States of America

Publisher:

National Academy of Sciences (U.S.)

Location:

Box: 40. Folder: 13

Rights:

Public Domain

Genre:

Articles

Subject:

Glucose, Metabolism, Potassium, Sodium, and Astrocytes

Format:

Text

Extent:

5 pages

Language:

English

Legacy Source Citation:

Periodical. Takahashi, Shinichi, Bernard F. Driscoll, Mona J. Law, Louis Sokoloff, and National Institute of Mental Health (U.S.). "Role of Sodium and Potassium Ions in Regulation of Glucose Metabolism in Cultured Astroglia." Proceedings of the National Academy of Sciences of the United States of America 92, 10 (May 1995): 4616-4620. Article. 5 Images.. Proceedings of the National Academy of Sciences of the United States of America

Legacy ID:

NLBBDX

NLM ID:

101743402X61

Profiles Collection:

The Louis Sokoloff Papers

Shareable Link:

https://profiles.nlm.nih.gov/101743402X61

Story Section:

Positron Emission Tomography Scanning and Beyond, 1979-2004