Brain Glucose Utilization in Mice with a Targeted Mutation in the Thyroid Hormone alpha or beta Receptor Gene

Title:
Brain Glucose Utilization in Mice with a Targeted Mutation in the Thyroid Hormone alpha or beta Receptor Gene
Creator:
Cheng, Sheue-Yann
Sokoloff, Louis
National Cancer Institute (U.S.)
Nunez, Jacques
National Institute of Mental Health (U.S.)
Kaneshige, Masahiro
Suzuki, Hideyo
Itoh, Yoshiaki
Esaki, Takanori
Cook, Michelle
Date:
14 August 2001
Description:
The study demonstrated that in mice a targeted mutation of the TRα thyroid hormone receptor that prevents it from binding thyroid hormone results in the same retardation of body growth and maturation of local cerebral glucose utilization as seen in cretinism produced by neonatal thyroidectomy whereas a corresplnding mutation in the TRβ thyroid hormone receptor has no such effects. This study demonstrates that thyroid binding to the TRα thyroid hormone receptor and not at all to the TRβ receptor is critical to the normal maturation of the brrain.
Periodical:
Proceedings of the National Academy of Sciences of the United States of America
Publisher:
National Academy of Sciences (U.S.)
Location:
Box: 40. Folder: 18
Rights:
Public Domain
Genre:
Articles
Subject:
Brain, Glucose, Mutation, and Thyroid Hormones
Format:
Text
Extent:
6 pages
Language:
English
Legacy Source Citation:
Periodical. Itoh, Yoshiaki, Takanori Esaki, Masahiro Kaneshige, Hideyo Suzuki, Michelle Cook, Louis Sokoloff, Sheue-Yann Cheng, Jacques Nunez, National Institute of Mental Health (U.S.), and National Cancer Institute (U.S.). "Brain Glucose Utilization in Mice with a Targeted Mutation in the Thyroid Hormone alpha or beta Receptor Gene." Proceedings of the National Academy of Sciences of the United States of America 98, 17 (14 August 2001): 9913-9918. Article. 6 Images.. Proceedings of the National Academy of Sciences of the United States of America
Legacy ID:
NLBBFB
NLM ID:
101743402X64
Profiles Collection:
The Louis Sokoloff Papers
Shareable Link:
https://profiles.nlm.nih.gov/101743402X64
Story Section:
Positron Emission Tomography Scanning and Beyond, 1979-2004