The Occurrence during Acute Infections of a Protein Not Normally Present in the Blood: III. Immunological Properties of the C-Reactive Protein and Its Differentiation from Normal Blood Proteins

Title:
The Occurrence during Acute Infections of a Protein Not Normally Present in the Blood: III. Immunological Properties of the C-Reactive Protein and Its Differentiation from Normal Blood Proteins
Creator:
Avery, Oswald Theodore, 1877-1955
MacLeod, Colin M. (Colin Munro), 1909-1972
Date:
February 1941
Description:
After detecting a new protein, the "C-reactive protein," in the serum of pneumonia patients, Avery and T. J. Abernethy set out to investigate what they believed to be an aspect of the infectious process that transcended the classic antigen-antibody reactions. Over the course of three papers in 1941, Avery and Abernethy, and later Avery and MacLeod, defined the characteristics of the protein and established that it was not an antibody. They cited evidence that the protein was instead released from tissue, likely as a result of cellular damage, and thus was a product of some nonspecific reaction of tissue to injury. Avery and MacLeod were further able to isolate the C-reactive protein as a highly purified, immunologically homogeneous protein.
Periodical:
Journal of Experimental Medicine
Publisher:
Rockefeller University. Press
Rights:
Reproduced from the Journal of Experimental Medicine, 1941, 73, 191-200, by copyright permission of the Rockefeller University Press.
Genre:
Articles
Format:
Text
Extent:
10 pages
Relation:
The Occurrence during Acute Infections of a Protein Not Normally Present in the Blood: I. Distribution of the Reactive Protein in Patients' Sera and the Effect of Calcium on the Flocculation Reaction with C Polysaccharide of Pneumococcus, 1941
The Occurrence during Acute Infections of a Protein Not Normally Present in the Blood: II. Isolation and Properties of the Reactive Protein, 1941
Language:
English
Legacy Source Citation:
Periodical. MacLeod, Colin M., and Oswald T. Avery. "The Occurrence during Acute Infections of a Protein Not Normally Present in the Blood: III. Immunological Properties of the C-Reactive Protein and Its Differentiation from Normal Blood Proteins." Journal of Experimental Medicine 73, 2 (February 1941): 191-200. Article. 10 Images.. Journal of Experimental Medicine
Legacy ID:
CCGMCY
NLM ID:
101584575X558
Profiles Collection:
The Oswald T. Avery Collection
Shareable Link:
https://profiles.nlm.nih.gov/101584575X558
Story Section:
DNA as the "Stuff of Genes": The Discovery of the Transforming Principle, 1940-1944